Sarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review
نویسندگان
چکیده
منابع مشابه
Sarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review.
UNLABELLED : Sarcomas are rare mesenchymal malignancies that demonstrate great clinical and biological heterogeneity. A variety of sarcomas develop in the context of well-defined heritable cancer predisposition syndromes, associations that are often overlooked, given the rarity and diversity of sarcomas and the equivalent relative infrequency of cancer genetic syndromes. This review describes i...
متن کاملComplex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes.
BACKGROUND The low incidence of sarcomas in the general population makes heritable contribution to disease risk difficult to discern beyond highly penetrant Mendelian syndromes. METHODS The Utah Cancer Registry (UCR) and Utah Population Database were interrogated for sarcoma diagnostic codes grouped by genetic type, either complex genotype/karyotype sarcoma or balanced translocation-associate...
متن کاملIndependent of Known Cancer Predisposition Syndromes Complex Genotype Sarcomas Display Familial Inheritance
Background: The low incidence of sarcomas in the general population makes heritable contribution to disease risk difficult to discern beyond highly penetrant Mendelian syndromes. Methods: The Utah Cancer Registry (UCR) and Utah Population Database were interrogated for sarcoma diagnostic codes grouped by genetic type, either complex genotype/karyotype sarcoma or balanced translocation-associate...
متن کاملGenetic syndromes associated with renal cell carcinoma: a review.
AIMS A review of recent knowledge on heredital syndromes related to renal cell carcinoma. METHODS Aim of this review was to summarize the recent knowledge of genetic syndromes associated with renal cell carcinoma. RESULTS Summary of incidence and factors modulating risk of hereditary renal cell carcinoma development. CONCLUSIONS Hereditary forms of RCC are relatively rare. Their study is ...
متن کاملGenetic predisposition syndromes and their management.
Apart from BRCA1, BRCA2, and TP53, more than a dozen breast cancer susceptibility genes have been identified. Recognizing affected individuals depends on evaluation of cancer family history and recognition of certain phenotypic markers on physical examination. Genetic testing provides a powerful tool for individualized risk stratification. Mutation carriers have several options for managing ris...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2016
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2016-0079